Projects

Publications

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. King C, McKenna A, Farzan N, Vijverberg SJ, van der Schee MP, Maitland-van der Zee AH, Arianto L, Bisgaard H, BØnnelykke K, Berce V, Potočnik U, Repnik K, Carleton B, Daley D, Chew FT, Chiang WC, Sio YY, Cloutier MM, Den Dekker HT, Duijts L, de Jongste JC, Dijk FN, Koppelman GH, Flores C, Hernandez-Pacheco N, Pino-Yanes M, Mukhopadhyay S, Basu K, Bignell L, Tantisira KG, Turner S, Verhamme KM, Francis B, Pirmohamed M, Sinha I, Hawcutt DB. Pharmacogenomics J. 2020 Jan 17. doi: 10.1038/s41397-019-0140-y

IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Dijk FN, Vijverberg SJ, Hernandez-Pacheco N, Repnik K, Karimi L, Mitratza M, Farzan N, Nawijn MC, Burchard EG, Engelkes M, Verhamme KM, Potočnik U, Pino-Yanes M, Postma DS, Maitland-van der Zee AH, Koppelman GH. Allergy. 2019 Nov 22. doi: 10.1111/all.14125

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, Oh SS, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland-van der Zee AH, Burchard EG, Pino-Yanes M. Clin Exp Allergy. 2019 Jun;49(6):789-798. doi: 10.1111/cea.13354.

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use. Farzan N, Vijverberg SJ, Hernandez-Pacheco N, Bel EHD, Berce V, Bønnelykke K, Bisgaard H, Burchard EG, Canino G, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Forno E, Francis B, Hawcutt DB, Herrera-Luis E, Kabesch M, Karimi L, Melén E, Mukhopadhyay S, Merid SK, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Repnik K, Schieck M, Sevelsted A, Sio YY, Smyth RL, Soares P, Söderhäll C, Tantisira KG, Tavendale R, Tse SM, Turner S, Verhamme KM, Maitland-van der Zee AH. Allergy. 2018 Oct;73(10):2083-2088. doi: 10.1111/all.13499.

The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand? Farzan N, Vijverberg SJ, Kabesch M, Sterk PJ, Maitland-van der Zee AH. Pediatr Pulmonol. 2018 Jun;53(6):836-845. doi: 10.1002/ppul.23976. 

Variants in genes coding for glutathione S-transferases and asthma outcomes in children. Turner S, Francis B, Vijverberg S, Pino-Yanes P, Mukhopadhyay S, Tavendale R, Palmer C, Burchard EG, Kebede Merid S, Melen E, Maitland-van der Zee AH, and on behalf of the Pharmacogenomics in Childhood Asthma Consortium. Pharmacogenomics. 2018 May; 19(8): 707–713.

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus BØnnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, Nicole F Dijk, Liesbeth Duijts, Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potocnik, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme & Anke H Maitland-van der Zee. Pharmacogenomics, 2017: 18(10):931-943. 

Childhood asthma exacerbations and the Arg16 beta2-receptor polymorphism: a meta-analysis stratified by treatment. Turner S, Francis B, Vijverberg S, Pino-Yanes M, Maitland van der Zee AH, Basu K, Bignell L, Mukhopadhyay S, Tavendale R, Palmer C, Hawcutt D, Pirmohamed M, Burchard EG, Lipworth B, Pharmacogenomics in Childhood Asthma Consortium. J. Allergy Clin Immunol. 2016: 138(1):107-113.e5

ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Vijverberg SJ, Koster ES, Tavendale R, Leusink M, Koenderman L, Raaijmakers JA, Postma DS, Koppelman GH, Turner SW, Mukhopadhyay S, Tse SM, Tantisira KG, Hawcutt DB, Francis B, Pirmohamed M, Pino-Yanes M, Eng C, Burchard EG, Palmer CN, Maitland-van der Zee AH. Clin Exp Allergy. 2015 Jun;45(6):1051-9

ADRB2 Arg16 and the need for collaboration in childhood asthma pharmacogenomics. Vijverberg SJ, Raaijmakers JA, Maitland van der Zee AH. Pharmacogenomics, 2013: 14(16):1937-9.